Johannesburg is the largest city and economic heart of South-Africa. People are starting to make it a "friendlier" city, away from the bad name of robbers and thieves. You still need to be careful, but a city tour to see the old and new Joburg is certainly worthwhile. Buying diamants? De Beers has its HQ here. Politics? Visit So-We-To (South-West Township) where Nelson Mandela lived.
The Kruger National Park is one of the largest game reserves in the world. The big five and many other animals have their home here. The location north-east of Johannesburg makes it an easy destination.
Capetown ("Kaapstad" in Afrikaans) is one of the most beautiful major cities in the world. It is the meeting point for two oceans with mountains and a natural harbor. Thanks to its nature many migrants moved there and movies were recorded there. Activities may include surfing, fishing, shark watching (!) or just walking and enjoying. Note that the area also produces good wines...
Blyde River Canyon (Dutch: "happy river canyon") is one of the largest and certainly greenest canyons on Earth.
Bloemfontein (Dutch: "Flower Fountain") is one of the three capitals of South-Africa and a major city. This could be a major connection or a stop for wine-drinking or ostrich riding.
The Drakensberg ("Dragons Mountain") escarpment is a mountain range in Eastern South Africa that includes features such as the Blyde River Canyon, Three Rondavels, and God's Window.
Kimberley is important as a Diamond Mining area.
Port Elizabeth is one of the largest cities in South-Africa. Portuguese, Dutch and English history left its traces.